金月芽期刊网

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  • Retrospective analysis of interventional treatment of hepatic metastasis from gastroenteropancreatic neuroendocrine tumors 相关:治疗 肿瘤
  • 表柔比星抑制大鼠门静脉分支结扎联合肝离断术后剩余肝再生的研究 相关: 门静脉 表柔比星
  • 目的 探讨表柔比星对大鼠门静脉分支结扎联合肝离断术后剩余肝的再生和肝功能的影响。方法 将96只雄性SD大鼠用随机化数字分为3组,每组32只。假手术组:仅游离肝周韧带及拟结扎门静脉分支后关腹;手术组:行肝尾叶、右叶、左叶、左中叶门静脉分支结扎+左右中叶肝实质离断;表柔比星+手术组:术前10 d静脉注射表柔比星(5 mg/kg),手术方式同手术组。观察术后24 h、72 h、7 d和10 d时各组剩余肝再生率、肝功能变化和肝脏组织形态学改变。结果 表柔比星+手术组术后7 d和10 d,剩余肝再生率分别为84.22%和113.26%,明显低于手术组的115.14%和128.90%(均P〈0.05)。术后第1天,手术组和表柔比星+手术组大鼠血清丙氨酸转氨酶、天冬氨酸转氨酶均急剧升高,且表柔比星+手术组明显高于手术组(P〈0.05),随后均逐渐下降,但表柔比星+手术组至术后10 d仍未恢复正常。血清白蛋白水平表柔比星+手术组在术后1 d后较假手术组和手术组低(均P〈0.05)。血清总胆红素水平各组各时间点均未见明显差别。表柔比星+手术组术后肝功能损害较重、恢复时间延长,肝脏组织形态学显示较明显损害。结论 表柔比星对大鼠门静脉分支结扎联合肝离断术后剩余肝再生和术后肝功能的恢复具有抑制作用。
  • 从季节与人生命阶段探讨“肝藏血、主疏泄”的调控机制 相关: 疏泄 藏血
  • 中医认为,在生命发展各个阶段中,自然环境与人体内环境之间具有一定的内在联系。人体内环境受外在环境影响并不断适应,其中,肝脏应时而变的调控作用是非常典型的。肝以疏泄为顺,以藏血为本,疏藏协调,气机调畅,气血运行正常则脏腑功能正常,此称为肝的调控功能。
  • 六步调节肝气郁结 相关:不良心理因素 消化系统
  • 瘤,到肝里,变成肝肿瘤。而病根就是肝气郁结。所以西医统计出来,80%的疾病与不良心理因素有关,这个不良心理因素,就是肝气郁结。甲状腺结节,乳腺结节,消化系统肿瘤,女性的大部分肿瘤,背后的“大老虎”,就是肝气郁结。
  • 当归芍药汤治疗妊娠腹痛病案2则 相关:妊娠腹痛 当归芍药汤
  • 妊娠腹痛自古以来都是困扰着妊娠妇女的一大问题,轻则影响孕妇的情绪及日常生活,重则引发流产。因此在临床上如何有效的缓解妊娠腹痛是我们目前一大任务。本篇文章主要根据“妇人之生,有余于气,不足于血”的生理特点,从肝脾入手来治疗妊娠腹痛。
  • “全无心肝” 相关: 亡国之痛 政治信仰
  • 陈朝后主陈叔宝亡国后当了俘虏,却全然没有亡国之痛,依然每天吃喝玩乐,吟诗唱和,三天两头喝得酩酊大醉,不省人事。不仅如此,后来陈叔宝竟对隋文帝要求:"我还没有一个称谓,每回朝集,无法与人交谈,愿得一官号。"文帝很轻蔑地说:"陈叔宝全无心肝。"意即他无信仰、无尊严、无操守、无羞耻。"全无心肝"者,古时有,今日也不少。在中纪委发布国家统计局原局长王保安"毫无政治信仰",安徽省委原常委、
  • 甜菜碱对热应激肉鸡肝肾功能损伤的缓解作用 相关:甜菜碱 肉鸡 热应激
  • 目的:研究热应激对肉鸡肝肾功能的影响及甜菜碱的缓解作用。方法:选择60只14 d的AA肉鸡,随机均分为对照组、热应激组和甜菜碱组,对照组按肉鸡标准饲养环境温度饲养;其余二组为热应激组,饲养温度设定为32±1℃。其中热应激组饮用自来水,甜菜碱组饮用0.2%的甜菜碱水溶液。分别饲喂至8、35 d,翅下静脉采血2 m L,分离血清,测定血清肝肾功能指标。结果:28 d时,热应激组与对照组相比,血清天门冬氨酸氨基转移酶、单胺氧化酶活性和尿酸、尿素氮、肌酐含量显著升高(P〈0.05或P〈0.01);甜菜碱组与热应激组相比,天门冬氨酸氨基转移酶活性、尿素氮、尿酸含量显著下降(P〈0.05或P〈0.01)。35 d时,热应激组与对照组对比,血清单胺氧化酶活性和尿酸、尿素氮、肌酐含量显著升高(P〈0.01)。甜菜碱组与热应激组对比,单胺氧化酶活性和血清尿素氮、肌酐含量显著降低(P〈0.05或P〈0.01)。结论:热应激可明显导致肝肾功能损伤,甜菜碱可以有效地缓解热应激对肉鸡肝肾功能的损伤。
  • Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract 相关:Metabotropic glutamate 受体子类型 5 食管
  • Metabotropic glutamate receptor subtype 5(mGluR5) is a Group I mGlu subfamily of receptors coupled to the inositol trisphosphate/diacylglycerol pathway. Like other m Glu R subtypes, mGluR5 s contain a phylogenetically conserved, extracellular orthosteric binding site and a more variable allosteric binding site, located on the heptahelical transmembrane domain. The mGluR5 receptor has proved to be a key pharmacological target in conditions affecting the central nervous system(CNS) but its presence outside the CNS underscores its potential role in pathologies affecting peripheral organs such as the gastrointestinal(GI) tract and accessory digestive organs such as the tongue, liver and pancreas. Following identification of mGluR5s in the mouth, various studies have subsequently demonstrated its involvement in mechanical allodynia, inflammation, pain and oral cancer. mGluR5 expression has also been identified in gastroesophageal vagal pathways. Indeed, experimental and human studies have demonstrated that mGluR5 blockade reduces transient lower sphincter relaxation and reflux episodes. In the intestine, mGluR5s have been shown to be involved in the control of intestinal inflammation, visceral pain and the epithelial barrier function. In the liver, mGluR5s have a permissive role in the onset of ischemic injury in rat and mice hepatocytes. Conversely, livers from mice treated with selective negative allosteric modulators and mGluR5 knockout mice are protected against ischemic injury. Similar results have been observed in experimental models of free-radical injury and in vivo mouse models of acetaminophen intoxication. Finally, mGluR5s in the pancreas are associated with insulin secretion control. The picture is, however, far from complete as the review attempts to establish in particular as regards identifying specific targets and innovative therapeutic approaches for the treatment of GI disorders.
  • Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury 相关:发炎 反应氧化应力 NRF2
  • AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI.
  • 从湿热论治青春期痤疮 相关:青春期痤疮 脾胃
  • 痤疮是青春期男女常见的多发病,慢性病,病程长且易反复发作。中医认为,青春期的痤疮病位多在脾胃、肝,与湿热相关,湿气重,湿从阳热化,发于肌肤而成痤疮。在治疗上从燥湿健脾,清肝,往往会收到满意效果。